Cancer is a complex disease characterized by uncontrolled cell growth, posing a significant health challenge worldwide. One of cancer's deadliest aspects is its ability to metastasize, wherein cancer cells spread from their primary site to other parts of the body, forming secondary tumors. The endothelial glycocalyx, a crucial component of the blood vessel wall, mediates interactions between circulating cancer cells and endothelial cells, influencing metastasis and secondary tumor formation. In this project, the team developed an in-vitro device that studied the role of the endothelial glycocalyx in the transendothelial migration of cancer cells. The system provided insights into the degradation of the glycocalyx and cancer cell migration potential as a function of shear stress.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Cocchiaro, Samantha
• Becka, Helga
• Elliott, Jacob
• Bushway, Kerry

Subject

• Innovation
• Project-Based Learning
• Health

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-042424-175151
• 121573

Keyword

• Lung Cells
• Transendothelial Migration
• Breast Cancer
• Endothelial Glycocalyx
• In- Vitro Flow System
• Cancer Metastasis

Advisor

• Mensah, Solomon

Year

• 2024

UN Sustainable Development Goals

• 3 - Good Health and Well-being
• 9 - Industry, Innovation and Infrastructure

Date created

• 2024-04-24

Resource type

• Major Qualifying Project

Major

• Biomedical Engineering

Source

• E-project-042424-175151

Rights statement

• In Copyright