Student Work
PGA as a drug delivery system for insulin
PublicThe utility of polyglutamic acid (PGA) as a drug delivery system was investigated using a cultured hepatic cell line (H35) and insulin conjugated to PGA. Glycogen synthase kinase-3 phosphorylation was monitored in cells exposed to varying degrees of free or PGA-conjugated insulin. Results suggest that PGA conjugated insulin, which is released by polymer degradation, remains biologically active and can bind insulin receptor and initiate a signal transduction cascade. Insulin-PGA results compare favorably to results using free insulin.
- This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
- Creator
- Publisher
- Identifier
- 00D090M
- Advisor
- Year
- 2000
- Date created
- 2000-01-01
- Resource type
- Major
- Rights statement
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