Abbott Bioresearch Center strives to characterize specific kinases in order to better understand the processes that take place in cells of the human body. The goal is to develop an inhibiting drug for a kinase pathway associated with a particular target disease. The main focus at Abbott is autoimmune diseases, including rheumatoid arthritis and pro-inflammatory diseases. This MQP details the initial process that each kinase goes through in order to understand compound inhibition under conditions that take into consideration the effects of a physiological environment, and shows the application to one specific kinase, COT. An inhibitor of the kinase was identified that acts in an ATP-competitive manner. These processes allow for screening of thousands of compounds against any kinase that can be isolated and characterized.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Gagnon, Andrew I.

Contributors

• Jia, Yong

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-121505-033950

Advisor

• Adams, David S.

Year

• 2005

Sponsor

• Abbott Bioresearch Center

Date created

• 2005-12-15

Resource type

• Major Qualifying Project

Major

• Biology & Biotechnology

Rights statement

• In Copyright

Last modified

• 2023-12-05