Candida albicans, an opportunistic pathogenic fungus, lives commensally in the human gut. Caenorhabditis elegans, an ideal host organism for microbiome studies, pre-exposed to the beneficial bacteria Bacillus subtilis are able to resist wildtype C. albicans infections and live longer than naive worms. We have identified C. albicans mutants that showed significant difference in lifespans of C. elegans with and without pre-exposure to B. subtilis. This approach will identify genes and pathways that modulate microbial interactions to alter host outcomes.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Friel, Erica R.

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-051620-144303

Advisor

• Rao, Reeta Prusty
• Argüello, José M.

Year

• 2020

Date created

• 2020-05-16

Resource type

• Major Qualifying Project

Major

• Biochemistry

Rights statement

• In Copyright