Senescence in CNS resident macrophages known as microglia, have been suspected to play key causational roles in neurodegenerative disease. This project aims to learn more about the potential causation and mechanisms that underlie senescent microglia’s role in diseased aging. To accomplish this, this research studied potential models of senescence in microglia. This investigation explores four different potential in vivo models of senescence in microglia in mice using pharmacological and genetic tools including Busulfan, p21 overexpression, Smurf2 overexpression, and transgenic Alzheimer’s Disease model mice.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Tsillas, Christina

Subject

• Health

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-042723-120401
• 106051

Advisor

• Skorinko, Jeanine LM
• Dempski, Robert E.
• Rodriguez, Angela C Incollingo

Year

• 2023

Sponsor

• Dorothy Schafer, Ph.D., University of Massachusetts Chan Medical School

Date created

• 2023-04-27

Resource type

• Major Qualifying Project

Major

• Biochemistry

Source

• E-project-042723-120401

Rights statement

• In Copyright

Last modified

• 2023-06-21