Paramyxoviruses are enveloped, negative-stranded RNA viruses that include such pathogens as Measles virus, Mumps virus, Parainfluenza virus and Newcastle disease virus (NDV), the focus of this Major Qualifying Project. Experimenting with co-expression of viral proteins HN and F from NDV and from other paramyxoviruses enabled us to hypothesize that heterologous co-expression of HN and F proteins result in down-regulation of HN expression. We conclude that this down-regulation is due to the misfolding of HN and its subsequent degradation in the proteasome.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Proia, David Arthur

Publisher

• Worcester Polytechnic Institute

Identifier

• 99D020M

Advisor

• Adams, David S.

Year

• 1999

Date created

• 1999-01-01

Resource type

• Major Qualifying Project

Major

• Biochemistry

Rights statement

• In Copyright