Drug-induced cardiotoxicity remains a primary reason why new pharmaceutical compounds are withdrawn from clinical trials and the consumer market. We have developed a novel cardiotoxicity screening device that utilizes cardiomyocytes seeded on fibrin microthreads to form a three-dimensional model for cardiac tissue. Our device can be used to analyze the contractile properties of these seeded threads. Upon the addition of pharmaceutical agents, the device has the potential to detect changes in contraction and thus identify cardiotoxic compounds.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Krill, John David
• O'Neil, Timothy Patrick
• Fekete, Juliana Kristina
• Mills, Cameron Scott

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-050114-094606

Advisor

• Gaudette, Glenn R.

Year

• 2014

Date created

• 2014-05-01

Resource type

• Major Qualifying Project

Major

• Biomedical Engineering

Rights statement

• In Copyright