The role of Cathepsin L in the innate immune system
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open in viewerDifferences in innate immune response to L. Monocytogenes infection are associated with genetic polymorphisms, and are studied using inbred mouse strains. Differences in susceptibility in BALB/c and C57BL/6J strains have been associated with the L2 locus of chromosome 13. Cathepsin L, which is located within this locus, was identified as a candidate susceptibility gene based on its differential expression in macrophages from these mice. A construct was created to analyze cathepsin L expression in macrophages. A novel mechanism of Ctsl regulation was discovered, which appeared to be controlled at a transcriptional level based on introduction of dsDNA or LPS. There were differences in this regulation pathway between the two mouse strains.
- This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
- Creator
- Publisher
- Identifier
- E-project-042711-101639
- Advisor
- Year
- 2011
- Sponsor
- Date created
- 2011-04-27
- Resource type
- Major
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