The Runx family of transcription factors are crucial for cell differentiation in a variety of systems. We investigated the involvement of Runx1 and 2 during the chondrogenesis of mesenchymal condensations. Using a model system of mouse embryonic fibroblasts in high-density cultures, we were able to recapitulate mesenchymal to chondrogenic differentiation in vitro. Our present study proposes that Runx1 may play a role in the induction of chondrogenesis, whereas Runx2 may play an anti-chondrogenic role in undifferentiated mesenchyme.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Lepper, Christoph

Publisher

• Worcester Polytechnic Institute

Identifier

• 03D183M

Advisor

• Adams, David S.

Year

• 2003

Date created

• 2003-01-01

Resource type

• Major Qualifying Project

Major

• Biology & Biotechnology

Rights statement

• In Copyright