Stress response, which is a complex interconnection of various pathways and proteins, has the capacity to protect an organism from cellular stress. Previous research in the Nechipurenko lab has shown that a non-canonical Gα protein guanine nucleotide exchange factor RIC-8 localizes to the primary cilium, and when heat shocked, the cilia of ric-8 mutant C. elegans are shorter than wild-type cilia. These preliminary findings suggest that RIC-8 contributes to protecting cilia against heat stress. The aims of this project were to determine whether RIC-8 is required for stress-dependent cilia remodeling and to identify additional genes involved in this process.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• LaBombard, Adam

Publisher

• Worcester Polytechnic Institute

Identifier

• 105691
• E-project-042723-002447

Keyword

• Bioinformatics
• Heat shock
• Heat stress
• Primary cilia
• C. elegans
• RIC-8

Advisor

• Ryder, Elizabeth F.
• Nechipurenko, Inna

Year

• 2023

Date created

• 2023-04-27

Resource type

• Major Qualifying Project

Major

• Bioinformatics & Computational Biology

Source

• E-project-042723-002447

Rights statement

• In Copyright

Last modified

• 2023-06-18