In prostate cancer, the development of normal to metastatic cells causes changes in integrin expression and the up-regulation of signaling pathways. Integrin b6 is known to be elevated in many types of epithelial cancers. The purpose of this study was to evaluate the expression of integrin B6 in benign vs. cancerous prostate tissue. Two different antibodies detected the presence of an antigenic epitope in the basal layer of epithelial cells, but tumor cells were negative. Staining is classified as artifact and the antibodies are not recognizing integrin B6.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Pereira, Gabriel L.

Publisher

• Worcester Polytechnic Institute

Identifier

• 05D405M

Advisor

• Buckholt, Michael Allan

Year

• 2005

Date created

• 2005-01-01

Resource type

• Major Qualifying Project

Major

• Biology & Biotechnology

Rights statement

• In Copyright

Last modified

• 2021-10-10