Modified dextran polymers as surfactants for emulsions in drug delivery
PublicModified dextran polymers are used as surfactants in oil in water emulsions, and serve as a hydrophobic boundary layer between the oil droplet surface and its aqueous surroundings, allowing for the formation stable emulsions that consist of biocompatible materials, a possible vector for drug delivery for oil-based drugs. These emulsions consist of Nujol (mineral) oil and a hydrophobically modified destran polymer solution (DexC, DexC, or DexP). Polymer solution concentrations greater than 5 grams per liter allowed for emulsion stability over long periods of time. A combination of centrifugation and lyophilization was determined to be a viable method for storage. Research was performed in collaboration with WPI and ENSIC.
- This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
- Creator
- Publisher
- Identifier
- 02D299M
- Advisor
- Year
- 2002
- Center
- Sponsor
- Date created
- 2002-01-01
- Resource type
- Major
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