The process of intracellular membrane fusion relies on several protein families, each playing multiple roles in assisting vesicle docking and SNARE assembly. Exocyst, a hetero-octameric protein complex, is proposed to tether vesicles to the plasma membrane and promote specific SNARE-mediated membrane fusion. Currently, the exocytic subunit Sec6 is proposed to bind both binary and ternary SNARE complexes during SNARE complex assembly. The timing in which Sec1, another SNARE regulator, binds to the ternary SNARE complex and the exocyst to mediate membrane fusion is unknown. Here, a summary is presented of the known interactions between two exocytic SNARE proteins and Sec1 with a single subunit of exocyst, Sec6.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Forson, Jacqueline

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-051820-152848

Advisor

• Scarlata, Suzanne Frances
• Munson, Mary
• Vidali, Luis

Year

• 2020

Sponsor

• Mary Munson

Date created

• 2020-05-18

Resource type

• Major Qualifying Project

Major

• Interdisciplinary

Rights statement

• In Copyright