Myocardial infarction occurs when oxygen is depleted from cardiac muscle. Post myocardial infarction, the left ventricular wall is weakened due to the formation of scar tissue. As a result, a ventricular aneurysm may occur. This project aims to find a method of reinforcing the weakened tissue and restoring normal cardiovascular function. A scaffold for cardiac regeneration will provide the long term reinforcement necessary to prevent ventricular aneurysms and restore normal heart function. This paper proposes a method of restoring cardiac tissue through the use of a novel implantation method using an hMSC seeded scaffold that will temporarily support the area of weakened tissue and aid in the production of cardiac myocytes to re-establish a healthy ventricular wall.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Sangillo, Emily P.
• Fredette, Gregory Albert
• Fakharzadeh, Michael

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-042108-132930

Advisor

• Gaudette, Glenn R.

Year

• 2008

Date created

• 2008-04-21

Resource type

• Major Qualifying Project

Major

• Biomedical Engineering

Rights statement

• In Copyright

License

• All rights reserved

Last modified

• 2021-01-06