A reverse genetic screen of Candida albicans mutants to understand its interaction with Bacillus subtilis within a live host Public
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Candida albicans, an opportunistic pathogenic fungus, lives commensally in the human gut. Caenorhabditis elegans, an ideal host organism for microbiome studies, pre-exposed to the beneficial bacteria Bacillus subtilis are able to resist wildtype C. albicans infections and live longer than naive worms. We have identified C. albicans mutants that showed significant difference in lifespans of C. elegans with and without pre-exposure to B. subtilis. This approach will identify genes and pathways that modulate microbial interactions to alter host outcomes.
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