High-throughput Maturation of Engineered Human Skeletal Muscle TissuePublic
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As pharmaceutical spending increases, the need for predictive disease models is ever rising. Tissue-engineered skeletal muscle (TESM) could offer functional units of human skeletal muscle tissue for high-throughput drug screening and may circumnavigate the non-predictive nature of most traditional preclinical model systems for musculoskeletal diseases. However, current TESM constructs are immature and lack biomimicry to native tissue. Tissue maturation strategies such as mechanical and electrical stimulation have been employed in an effort to improve biomimicry, and have been demonstrated to improve myofiber alignment, protein expression, and contractile ability. In this MQP, a device was designed to mechanically and electrically stimulate TESM constructs in a high-throughput manner.
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