Based on the large prevalence of chronic kidney disease across the globe, there exists a need to fully understand and improve upon current peritoneal dialysis (PD) treatments that contribute to physiological changes in the peritoneum leading to diseases such as ultrafiltration failure. The proposed microfluidic model serves as a physiologically accurate model of the fibrotic peritoneum seen clinically in patients undergoing PD. The microfluidic model is designed as a tool for researchers to run cell culture experiments to evaluate interactions of dialysate fluid with various cell types present in the fibrotic peritoneum. The model developed is a lower-cost and higher-throughput option than current gold-standard animal models also accounting for practical and ethical considerations.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Rivera, Gabriel
• Caldwell, Cleo
• Baeza Gonzalez, Araceli
• Drapeau, Alison

Subject

• Industry
• Health
• Innovation

Publisher

• Worcester Polytechnic Institute

Identifier

• 105816
• E-project-042723-095326

Stichwort

• Fibrosis
• Peritoneal Dialysis
• Microfluidics
• Ultrafiltration Failure
• Interstitial Flow

Advisor

• Whittington, Catherine Faye

Year

• 2023

UN Sustainable Development Goals

• 9 - Industry, Innovation and Infrastructure
• 12 - Responsible Consumption and Production

Date created

• 2023-04-27

Resource type

• Major Qualifying Project

Major

• Biomedical Engineering

Source

• E-project-042723-095326

Rights statement

• In Copyright

Zuletzt geändert

• 2023-06-23