This Major Qualifying Project investigated blood testing as a noninvasive detection method and evaluation of the risk of Unruptured Intracranial Aneurysms (UIAs). By mimicking hypertension with manipulation of blood pressure and vascular wall repair inhibitors in the rabbit samples, it was hypothesized that there would be an increase in antibodies produced which will readily bind to the AFHYESQ peptide. Our results show a positive correlation between increase in blood pressure and increase in titer, which indicate more presence of bound antibodies, showing a more prevalent immune response to the AT1R. An ELISA assay was used for all serum samples, which can now be expanded to other models for continuous sampling.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Puckett, Stephanie Michelle
• Schozer, Anna Leigh

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-041917-140420

Advisor

• Brodeur, Drew R.

Year

• 2017

Sponsor

• UMASS

Date created

• 2017-04-19

Resource type

• Major Qualifying Project

Major

• Chemistry

Rights statement

• In Copyright