Defining the role of a conserved G protein activator RIC-8 in neuronal heat shock responsePublic
Downloadable Contentopen in viewer
Stress response, which is a complex interconnection of various pathways and proteins, has the capacity to protect an organism from cellular stress. Previous research in the Nechipurenko lab has shown that a non-canonical Gα protein guanine nucleotide exchange factor RIC-8 localizes to the primary cilium, and when heat shocked, the cilia of ric-8 mutant C. elegans are shorter than wild-type cilia. These preliminary findings suggest that RIC-8 contributes to protecting cilia against heat stress. The aims of this project were to determine whether RIC-8 is required for stress-dependent cilia remodeling and to identify additional genes involved in this process.
- This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
- Date created
- Resource type
- Rights statement
- Last modified
- In Collection:
Permanent link to this page: https://digital.wpi.edu/show/7h149t195