Chronic diseases are a prevalent and expensive health conditions in the US, with 133 million people suffering from a chronic disease. Tissue engineering, particularly mesenchymal stem cell(MSC) approaches, show great potential in meeting the need for treatments. There is a need for an improved scaffold to promote proliferation of adherent cells within bioreactors. This project aims to solve this gap in technology by constructing a 3-D scaffold of a novel material that would solve production issues of MSC’s. A literature review found materials that were nontoxic, flexible, and allowed cellular adhesion. Experiments quantified cell seeding and proliferation on varying materials to select a material for final design. A multilayer scaffold of stainless steel mesh was selected for final design.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Coutts, Colin William
• Donovan, Emily
• Suchanek, Kyle Stephen
• Nikulina, Maria

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-051320-130755

Advisor

• Rao, Pratap M.
• Page, Raymond L.

Year

• 2020

Date created

• 2020-05-13

Resource type

• Major Qualifying Project

Major

• Biomedical Engineering

Rights statement

• In Copyright