A Three-Dimensional (3D) In Vitro Model of Ehlers-Danlos Syndrome
Público DepositedClassical Ehlers-Danlos Syndrome (cEDS) disrupts collagen structure, leading to delayed wound healing which negatively impacts patients’ quality of life. There exists a need to create treatments to aid in the cEDS wound healing process; however, the mechanisms behind this impaired wound healing are not fully understood. Wound healing models provide an opportunity to further identify disease characteristics and serve as a tool for pharmacological testing. Existing wound healing models are either not sufficiently representative of the disease or are expensive and complex to fabricate. This project aimed to engineer a 3D in vitro wound healing model of cEDS. A 3D in vitro cell-seeded fibrin gel model was engineered, supported by cell-count studies, wound healing monolayer assays, outgrowth assays, and indentation tests. Findings demonstrate the model may serve as a representative tool to improve the general understanding of wound healing in cEDS.
- This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
- Creator
- Publisher
- Identifier
- 121495
- E-project-042424-123115
- Palavra-chave
- Advisor
- Year
- 2024
- Date created
- 2024-04-24
- Resource type
- Major
- Source
- E-project-042424-123115
- Rights statement
- Última modificação
- 2024-05-28
Relações
- Em Collection:
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MQP_BME_37401_Final_Report.pdf | Público | Baixar | |
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MQP_BME_37401_Final_Presentation.pptx | Público | Baixar |
Permanent link to this page: https://digital.wpi.edu/show/0r9678293