Student Work
Computational analysis of viral sequences similar to complement regulators
PublicComputational analysis was performed on amino acid sequences of poxviruses and herpesviruses to show relationships to human complement regulators, factor H and C4 binding protein -chain (C4bp). Sequence alignments and phylogenetic trees have demonstrated that all viral proteins studied are similar to both complement regulators. Poxviruses showed a higher similarity to C4bp. A number of individual domains of the viral sequences show similarity to the functional regions of human complement regulators, explaining their role in modulating the host immune response.
- This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
- Creator
- Publisher
- Identifier
- 01D258M
- Advisor
- Year
- 2001
- Date created
- 2001-01-01
- Resource type
- Major
- Rights statement
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