Probiotics are used to maintain a healthy gut microbiome. Although Candida albicans is part of our natural microbiota, dysbiosis has been associated with Crohn’s disease and Irritable Bowel Syndrome. Our project evaluates the interactions between C. albicans and the probiotic Bacillus subtilis on the health and longevity of Caenorhabditis elegans, a model host. Our findings will identify genes and pathways that regulate microbial interactions in the gut and inform antifungal drug development.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Frederick, Dawn
• Cimino, Emily

Subject

• Well-Being
• Project-Based Learning
• Health

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-042722-134842
• 64366

Keyword

• gut microbiome
• C. elegans
• Bacillus subtilis
• Candida albicans

Advisor

• Rao, Reeta Prusty

Year

• 2022

UN Sustainable Development Goals

• 3 - Good Health and Well-being

Date created

• 2022-04-27

Resource type

• Major Qualifying Project

Major

• Biology & Biotechnology

Rights statement

• In Copyright