Student Work

Analysis of an inhibitor of the Epidermal Growth Factor Receptor

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ErbB2, a receptor tyrosine kinase and member of the human EGFR family, is implicated in 30% of all breast cancers. Studies have recently shown that the Drosophila EGF receptor (DER) is structurally analogous to ErbB2. The transmembrane protein, Kek1, has been shown to bind and inhibit DER. By defining sequence elements important for this binding and inhibition, I hope to gain insight that may provide an opportunity to generate ErbB2-specific cancer therapeutics.

  • This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
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Identifier
  • E-project-042711-175209
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Year
  • 2011
Date created
  • 2011-04-27
Resource type
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