Effects of Chronic and Acute Arsenic Exposure On the Cellular Stress Response Public
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Arsenic contamination of water supplies is a global concern. Stress granules (SGs) are cytoplasmic aggregations of RNA and protein formed in response to myriad environmental stresses, including arsenic. Acute and sub-lethal chronic levels of arsenic were tested for effects on SG formation. High level acute arsenic exposure resulted in maximal SG formation while low acute exposure had comparable results to sub-lethal chronic exposure. The results suggest that even trace amounts of heavy metals, when exposed chronically, cause considerable cellular stress.
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