Investigating the Role of MycN and p53 Binding in Pediatric Neuroblastoma Public
Downloadable ContentDownload PDF
Neuroblastoma is the most common extracranial solid tumor found in children and accounts for 13-15% of all pediatric cancer deaths. Amplification of MycN is one of the strongest indicators of poor prognosis and is present in 50% of all high-risk cases of neuroblastoma; its role in neuroblastoma has not been clearly elucidated, but evidence suggests that it binds to the C-terminal domain of p53 and alters its response to genotoxic stress. The binding of p53 and MycN is a novel discovery; more investigation into the role of p53-MycN binding can provide insight into neuroblastoma tumorigenesis and potentially other MycN-amplified cancers. This project sought to further investigate the role of MycN and p53 binding in neuroblastoma and to outline further research on the novel interaction.
- Date created
- Resource type
- Rights statement
Permanent link to this page: https://digital.wpi.edu/show/xw42nb38p