Search for Novel Anti-Inflammatory Drugs by Screening Chiral Conjugates of the Endocannabinoid – NAGly
PúblicoThroughout human history, people have been plagued by inflammation. Marijuana has been documented numerous times in recorded history for its ability to alleviate the symptoms of inflammation. The endocannabinoid N-arachidonyl-glycine (NAGly) has been shown induce the resolution of inflammation. In this project, chiral analogs of NAGly were synthesized and screened for anti-inflammatory effects. The results confirmed the stereo-selectivity, previously noted by Burstein and colleagues, favoring the D-isomers over the L-isomers. Therefore, further research projects seeking to design new pharmaceuticals should develop larger drug libraries of elmiric acids focusing on the D-isomers.
- This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
- Creator
- Publisher
- Identifier
- E-project-102710-171139
- Advisor
- Year
- 2010
- Sponsor
- Date created
- 2010-10-27
- Resource type
- Major
- Rights statement
Relações
- Em Collection:
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Ben_Seicol_MQP_Final_Draft.pdf | Público | Baixar |
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