Search for Novel Anti-Inflammatory Drugs by Screening Chiral Conjugates of the Endocannabinoid – NAGly
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open in viewerThroughout human history, people have been plagued by inflammation. Marijuana has been documented numerous times in recorded history for its ability to alleviate the symptoms of inflammation. The endocannabinoid N-arachidonyl-glycine (NAGly) has been shown induce the resolution of inflammation. In this project, chiral analogs of NAGly were synthesized and screened for anti-inflammatory effects. The results confirmed the stereo-selectivity, previously noted by Burstein and colleagues, favoring the D-isomers over the L-isomers. Therefore, further research projects seeking to design new pharmaceuticals should develop larger drug libraries of elmiric acids focusing on the D-isomers.
- This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
- Creator
- Publisher
- Identifier
- E-project-102710-171139
- Advisor
- Year
- 2010
- Sponsor
- Date created
- 2010-10-27
- Resource type
- Major
- Rights statement
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La vignette | Titre | Visibilité | Embargo Release Date | actes |
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Ben_Seicol_MQP_Final_Draft.pdf | Public | Télécharger |
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