Throughout human history, people have been plagued by inflammation. Marijuana has been documented numerous times in recorded history for its ability to alleviate the symptoms of inflammation. The endocannabinoid N-arachidonyl-glycine (NAGly) has been shown induce the resolution of inflammation. In this project, chiral analogs of NAGly were synthesized and screened for anti-inflammatory effects. The results confirmed the stereo-selectivity, previously noted by Burstein and colleagues, favoring the D-isomers over the L-isomers. Therefore, further research projects seeking to design new pharmaceuticals should develop larger drug libraries of elmiric acids focusing on the D-isomers.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Seicol, Benjamin Joseph

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-102710-171139

Advisor

• Heilman, Destin

Year

• 2010

Sponsor

• UMass Medical School

Date created

• 2010-10-27

Resource type

• Major Qualifying Project

Major

• Biochemistry

Rights statement

• In Copyright