Search for Novel Anti-Inflammatory Drugs by Screening Chiral Conjugates of the Endocannabinoid – NAGly Public
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Throughout human history, people have been plagued by inflammation. Marijuana has been documented numerous times in recorded history for its ability to alleviate the symptoms of inflammation. The endocannabinoid N-arachidonyl-glycine (NAGly) has been shown induce the resolution of inflammation. In this project, chiral analogs of NAGly were synthesized and screened for anti-inflammatory effects. The results confirmed the stereo-selectivity, previously noted by Burstein and colleagues, favoring the D-isomers over the L-isomers. Therefore, further research projects seeking to design new pharmaceuticals should develop larger drug libraries of elmiric acids focusing on the D-isomers.
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