Correlate Analyses for Acutely Infected HIV Individuals: Natural Disease Control StudyPublic
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The human immunodeficiency virus (HIV) infects ~5,000 new people daily. Only a small population of infected individuals are natural viral controllers. The goal of this project was to determine humoral factors that correlate to HIV controller versus progressor status. Multivariate and univariate data analyses compared HIV-specific IgG subclasses and antibody-dependent effector functions of controllers and progressors measured at acute infection. Multivariate approaches were effective in differentiating controllers from progressors, suggesting no single antibody feature is predictive of disease control.
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