Small Scale Scale Continuous Flow Bioreactor for Enhanced Adherent Cell CulturePublic
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Most of the processes in the biomanufacturing industry utilize suspension bioreactor for the production of biologics, whereas there has been a slower development in large scale manufacturing involving adherent cell cultures. This project aims to design a novel bioreactor system which supports adherent cell culture, while improving upon cellular adherence and volumetric efficiency. The final design incorporated a packed bed of microcarriers within a continuous pumping system, thereby promoting bead-to-bead migration and the recycling of unattached cells. The system was tested for proper continuous fluid flow, and the microcarriers were optimized to maximize surface area and cellular attachment potential.
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