The Epidermal Growth Factor or ErbB family of receptor tyrosine kinases has been the focus of cancer therapeutics based on their involvement in numerous cancer types, including lung, breast and brain. This pathway is conserved from humans to flies (Drosophila) making Drosophila a good model organism for ErbB cancer related studies. Toward this goal, transgenic flies were generated with ErbB3 and ErbB4 members of the ErbB family. Moreover, functional studies demonstrated that ErbB4 is indeed active in Drosophila providing a novel avenue for research opportunities in the field of cancer therapeutics.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Ayisi, Samuel

贡献者

• Arata, Michelle
• Haridas, Harita

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-011411-145044

Advisor

• Duffy, Joseph B.

Year

• 2011

Date created

• 2011-01-14

Resource type

• Major Qualifying Project

Major

• Biology & Biotechnology

Rights statement

• In Copyright