In this project, we studied transcriptional regulation in C. elegans through a network approach. We used techniques analyzing degree distribution, motifs, gene regulation subgraphs etc. to investigate various properties of the network. Our motif analysis discovered previously unknown motifs that are likely to have biological significance. We introduced a new technique for quantifying amount of gene regulation and formulated a new hypothesis to predict autoregulation. Our results will serve as a basis for future biological experiments.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Vartak, Manasi Pradeep

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-042910-092328

Advisor

• Servatius, Brigitte

Year

• 2010

Sponsor

• University of Massachusetts Medical School

Date created

• 2010-04-29

Resource type

• Major Qualifying Project

Major

• Mathematical Sciences

Rights statement

• In Copyright