Porcine Circovirus Type 1 (PCV1) is a member of the Circoviridae family. The protein encoded by its third open reading frame (PCV1 VP3) displays onco-specific induction of apoptosis; localization signals have been implicated in this onco-specific activity. Site-directed mutagenesis was applied to assess the functionality of export sequences within PCV1 VP3. The cytoplasmic localization observed after the mutations raise many questions as to the functionality of these export sequences and the possible existence of non-classical sequences within PCV1 VP3.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Mahoney, Brittany Lee
• Clancey, Sarah Theresa

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-042413-140338

Advisor

• Heilman, Destin

Year

• 2013

Date created

• 2013-04-24

Resource type

• Major Qualifying Project

Major

• Biochemistry

Rights statement

• In Copyright