A Liquid Assay for Screening Fungal Virulence FactorsPublic
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It is difficult to develop drugs against fungal infections due to the fact that both fungi and their hosts are eukaryotic. Using a model host-pathogen system, factors involved in the infection can be identified and studied. By using these two genetic model organisms and this assay in high-throughput screens of genetic knockouts, fungal virulence factors can be identified. We are developing a liquid culture assay for studying the effects of co-culturing Caenorhabditis elegans with Saccharomyces cerevisiae mutants. From the results of all the experiments, we concluded that there are other factors that can cause the death of the C. elegans in liquid assay which are not S. cerevisiae related.
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