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A Liquid Assay for Screening Fungal Virulence Factors

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It is difficult to develop drugs against fungal infections due to the fact that both fungi and their hosts are eukaryotic. Using a model host-pathogen system, factors involved in the infection can be identified and studied. By using these two genetic model organisms and this assay in high-throughput screens of genetic knockouts, fungal virulence factors can be identified. We are developing a liquid culture assay for studying the effects of co-culturing Caenorhabditis elegans with Saccharomyces cerevisiae mutants. From the results of all the experiments, we concluded that there are other factors that can cause the death of the C. elegans in liquid assay which are not S. cerevisiae related.

  • This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
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  • 2021-02-02
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  • E-project-042408-154851
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  • 2008
Date created
  • 2008-04-24
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