Student Work
Truncation mutagenesis of Porcine Circovirus 1 VP3 uncovers the importance of the C-terminal extended region in inducing apoptosis of human cancer cells
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open in viewerPorcine Circovirus Type 1 (PCV1) third viral protein (VP3) has been shown to induce apoptosis in cancer cells. Sequence analysis revealed that PCV1 VP3 contains an N-terminal region homologous to its apoptotic homolog, VP3 of Chicken Anemia Virus, and a C-terminal extended region. This study successfully developed a method to quantitatively assess and identity the region responsible for PCV1 VP3’s apoptotic activity. Our apoptosis studies suggest that the C-terminal region is responsible for the robust apoptosis-inducing property of PCV1 VP3.
- This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
- Creator
- Publisher
- Identifier
- E-project-043015-153412
- Advisor
- Year
- 2015
- Date created
- 2015-04-30
- Resource type
- Major
- Rights statement
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Thumbnail | Title | Visibility | Embargo Release Date | Actions |
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PCV1_VP3_region_responsible_for_killing_cancer_cells.pdf | Public | Download |
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