Although cardiac natriuretic peptides (NPs) have well characterized roles as vasodilators, recent evidence indicates some NPs may also act to help regulate carbohydrate metabolism in brown fat. The purpose of this project was to examine whether ventricular (or brain-type) natriuretic peptide (B-type, BNP) affects glucose metabolism in tissues other than brown fat, especially in mouse skeletal muscle. Mice were fed a high-fat diet for 8 weeks, then glucose uptake in muscle was assayed using 2-[14C]-deoxyglucose-6-phosphate, and glycogen synthesis was monitored using 3H-glucose labeling into muscle glycogen. The data indicate that BNP treatment did not alter glucose metabolism in skeletal muscle, so perhaps BNP has no glucose metabolic effect on this particular peripheral tissue.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Binny, Monolina Habib

贡献者

• Kim, Jason

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-042114-135835

Advisor

• Adams, David S.

Year

• 2014

Sponsor

• Umass Medical Center

Date created

• 2014-04-21

Resource type

• Major Qualifying Project

Major

• Biology & Biotechnology

Rights statement

• In Copyright