Investigating Influenza A Hemagglutinin using Pseudoviruses Public
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The rise of Influenza A virus (IAV) infections continues to fuel a global epidemic due to rapid mutations within the virus and its ability to cross between species. In northeastern seal populations, this antigenic shift is observed in maternal antibodies found in sera samples of seal pups. However, the chances of identifying and propagating live viruses from these samples are extremely low. An alternative approach is to use a pseudovirus (PV), which is a non-infectious viral particle that can be built to express select surface proteins. Our aim is to develop a panel of PVs, each of which carries a single sub-type of hemagglutinin (HA). We hypothesize that a PV will be able to identify the HA-subtype of an IAV from these seal samples and observe emerging IAV trends.
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