Magnetic resonance imaging (MRI) was used for accurate and dynamic monitoring of tissue embedded microthreads; a novel biomaterial utilized to promote cardiac regeneration. An in vitro cardiac modeling system was developed that mimicked the MRI properties of native cardiac tissue by using gelatin of varying concentrations. Microthreads were treated with an iron-based superparamagnetic MRI contrast agent (ferumoxtran), embedded into the cardiac modeling system, and then imaged using MRI. T1- and T2-weighted MR images showed no statistical difference between actual thread location and diameter when compared with the same measurements obtained from optical images of the same cardiac modeling system.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Bisa, Jayanth
• Gonsalves, Matthew A.
• Demers-Peel, Evan Arthur

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-042910-105806

Advisor

• Pins, George D
• Sotak, Christopher H.

Year

• 2010

Sponsor

• University of Massachusetts Medical School

Date created

• 2010-04-29

Resource type

• Major Qualifying Project

Major

• Biomedical Engineering

Rights statement

• In Copyright

最新修改

• 2021-02-01