Is a precursor to the anti-malarial drug, artemisinin, glycosylated in planta? Public
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A precursor of the anti-malarial drug, artemisinin (AN), artemisinic acid (AA) can be glycosylated in vitro by suspension cells of A. annua. This project sought to confirm the presence of conjugated AA in whole plants of A. annua. Extracts were hydrolyzed to test for increases in the cleaved terpenoids. Increases were observed in treated shoots after acid hydrolysis and glucosidase treatment, indicating the presence of the conjugates in shoots. AA was not observed after any treatment of root residues.
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