The main challenge associated with engineering avascular tissue such as cartilage is overcoming the physiological nutrient perfusion limit of 100 µm. Using a 3D printer, a PLA tissue scaffold with a diameter of 6.2 mm was fabricated. The scaffold was threaded with degradable collagen sutures and filled with a chondrogenic cell line suspended in a 4% alginate hydrogel. The scaffold system successfully supported cell proliferation and differentiation for 1 week, indicating efficient nutrient perfusion to the center of the scaffold.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Thomas, Patrick Edward
• D'Alesio-Spina, Gaetana A
• Calvao, Dominick Joseph

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-042915-230907

Advisor

• Ambady, Sakthikumar
• Albrecht, Dirk

Year

• 2015

Date created

• 2015-04-29

Resource type

• Major Qualifying Project

Major

• Biomedical Engineering

Rights statement

• In Copyright