This project developed a computational biology tool that discovers regulatory regions in DNA and their impact on gene expression. The MAGE computer system, utilizing three software components, predicts gene expression in cells. Motifs or patterns in the promoter regions, from both the C. elegans and C. briggsae genomes, were found using the expectation maximization and Gibbs algorithms. These motifs were mined and used to build association rules models that predict cell specific expression. The accuracy of various models was assessed.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Baird, John Lee
• Monteiro, Kenneth Richard
• Gougian, Rebecca Susan
• Young, Paul J.
• Farmer, Jason Zane

Publisher

• Worcester Polytechnic Institute

Identifier

• 03D139M

Advisor

• Ryder, Elizabeth F.
• Ruiz, Carolina

Year

• 2003

Date created

• 2003-01-01

Resource type

• Major Qualifying Project

Major

• Electrical & Computer Engineering
• Computer Science
• Biology & Biotechnology

Rights statement

• In Copyright