Triple negative metastatic breast cancer (mTNBC) accounts for 15% of breast cancer but remains not fully curable. The lack of modern knowledge regarding the tumor microenvironment has prevented the development of effective therapies and cancer drug screening. Current drug testing models do not adequately recapitulate the tumor microenvironment, leading to patients receiving treatments with unexpected adverse effects. To bridge this gap, a patient specific tumor microenvironment model was developed to test therapies in vitro. Using the model, tissue rings of various shapes composed of both MB-MDA-231 and Fibroblast cells were generated to analyze cell behavior under different mechanical stresses. This may better reflect the patient specific cancer tumor anatomy for more accurate screening results and more effective therapeutic approaches.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Corona Parra, Luis Eduardo E.
• Scott, Matthew J.
• Marzoratti, Alejandro M.

Publisher

• Worcester Polytechnic Institute

Identifier

• 22941
• E-project-050621-125601

Keyword

• Cancer
• Metastasis
• Tissue
• Tumor-Model
• Theraputics
• Microenvironment

Advisor

• Page, Raymond L.

Year

• 2021

Sponsor

• Professor Raymond Page

Date created

• 2021-05-06

Resource type

• Major Qualifying Project

Major

• Biomedical Engineering

Rights statement

• In Copyright