Drug screening is an expensive process. Due to the limitations of preclinical testing, most drugs fail during clinical trials. No system currently available can determine a drug’s effect on each organ in relation to one another. This project presents the novel use of decellularized leaves seeded with human cells connected on the same recirculating perfusion system for drug screening purposes. In our system, each leaf is seeded with a different cell type. By interconnecting these leaves, we can study cell interactions for drug screening purposes. Testing has shown that our system can successfully decellularize spinach leaves, and human cells can be successfully seeded onto the surface of these leaves.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Gotts, Lindsay Guoying
• Porter, Nathaniel R.
• Marotta, Alison L.
• Jones, Jordan Darnell
• Thyden, Richard Eric

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-042516-121739

Advisor

• Gaudette, Glenn R.

Year

• 2016

Date created

• 2016-04-25

Resource type

• Major Qualifying Project

Major

• Biomedical Engineering

Rights statement

• In Copyright