GABA is the primary inhibitory neurotransmitter in the CNS that causes late inhibitory postsynaptic potentials when transmitted to metabotropic GABA-B receptors. GABA-B receptors are comprised of two subunits whose dimerization is required for function. Using bioinformatic methods we have found a possible GABA-B R3 subunit in Drosophila melanogaster. The presence of the Drosophila GABA-B clones were identified by PCR but not cloned in full length. Discovery of a GABA-B R3 clone may facilitate drug discovery for treatments of many CNS diseases.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Santos, Amanda Patricia

Publisher

• Worcester Polytechnic Institute

Identifier

• 00D118M

Advisor

• Adams, David S.

Year

• 2000

Sponsor

• AstraZeneca

Date created

• 2000-01-01

Resource type

• Major Qualifying Project

Major

• Biology & Biotechnology

Rights statement

• In Copyright