Student Work
Identification of three Drosophila melanogaster GABA-B DNA clones
ÖffentlichGABA is the primary inhibitory neurotransmitter in the CNS that causes late inhibitory postsynaptic potentials when transmitted to metabotropic GABA-B receptors. GABA-B receptors are comprised of two subunits whose dimerization is required for function. Using bioinformatic methods we have found a possible GABA-B R3 subunit in Drosophila melanogaster. The presence of the Drosophila GABA-B clones were identified by PCR but not cloned in full length. Discovery of a GABA-B R3 clone may facilitate drug discovery for treatments of many CNS diseases.
- This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
- Creator
- Publisher
- Identifier
- 00D118M
- Advisor
- Year
- 2000
- Sponsor
- Date created
- 2000-01-01
- Resource type
- Major
- Rights statement
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