Student Work
GENERATION OF TRANSGENIC MICE WITH A HEART-SPECIFIC DELETION OF THE JNK-1 & 2
PublicDownloadable Content
open in viewerThe purpose of this project was to generate a mouse line containing a heart-specific deletion of genes encoding JNK-1 and -2, which may map to insulin-resistance, to create a model for studying the effects of type II diabetes on cardiomyocytes. The Cre/loxP recombination system was used in a C57BL/6 mouse, with Cre under the control of a MHC promoter to drive expression in cardiomyocytes. PCR analysis showed the creation of 3 Cre-positive mice for JNK1, and 3 for JNK2, providing mice which can be used to determine the potential role of JNK1 and JNK2 in insulin-resistance in heart cells.
- This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
- Creator
- Publisher
- Identifier
- E-project-042712-182216
- Advisor
- Year
- 2012
- Sponsor
- Date created
- 2012-04-27
- Resource type
- Major
- Rights statement
Relations
- In Collection:
Items
Items
Thumbnail | Title | Visibility | Embargo Release Date | Actions |
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Adeola_and_Dimitri_MQP_Final.pdf | Public | Download |
Permanent link to this page: https://digital.wpi.edu/show/sj139341t