This project seeks to understand the dynamics of DNA damage repair in cancerous cells utilizing preexisting software and novel analysis approaches. Current analysis tools allow biologists to independently track cell movement and count damage sites, but not simultaneously. Our methods identified a slight increase in damage frequency over time in motile cell populations. We suggest utilizing cell morphology rather than coordinate tracking for further advancements in this area.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Nicolella, Alyssa Alexandra
• Corace, Michael L.

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-051820-163444

Advisor

• Manning, Amity L.
• Korkin, Dmitry

Year

• 2020

Date created

• 2020-05-18

Resource type

• Major Qualifying Project

Major

• Bioinformatics & Computational Biology

Rights statement

• In Copyright

License

• All rights reserved