Porcine Circovirus Type 2 (PCV2) contains a protein, VP3, that can induce apoptosis in cancerous cells. PCV2 is commonly compared to Chicken Anemia Virus (CAV) because of its similar protein apoptin, which also induces apoptosis in cancerous cells. An increase in nuclear accumulation when PCV2 VP3 cells were treated with Leptomycin B provided evidence that PCV2 VP3 may utilize the same CRM1 pathway that apoptin does, but it is not the only method at work. The proteins were then cotransfected, but did not show any changes in localization. The conjunction of the results illustrate that although the two viruses may carry out a similar function, they may utilize completely different mechanisms.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Hanley, Amanda Rose

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-082213-112916

Advisor

• Heilman, Destin

Year

• 2013

Date created

• 2013-08-22

Resource type

• Major Qualifying Project

Major

• Biology & Biotechnology

Rights statement

• In Copyright