MIG-10 is a C.elegans protein known to stimulate lamellipodia formation in directed neuronal migration and cause truncation of the excretory canal. MIG-10 was found to physically interact with Ableson Interacting Protein 1 (ABI-1) in vitro, which is being confirmed by Co-IP. The proteins' interaction in vivo was studied using RNAi expression knockdown. MIG-10 mutants showed increased truncation of the excretory canal when fed ABI-1 RNAi. We concluded that MIG-10 and ABI-1 may reside in different pathways, but have overlapping functions.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Baldiga, Christina E.
• Dubuke, Michelle L.

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-043009-121202

Advisor

• Ryder, Elizabeth F.

Year

• 2009

Date created

• 2009-04-30

Resource type

• Major Qualifying Project

Major

• Biochemistry
• Biology & Biotechnology

Rights statement

• In Copyright

Last modified

• 2021-02-02